Cromoglycate sodium
cromolyn sodium
CAS: 15826-37-6
Molecular Formula: C23H14O11Na2
Cromoglycate sodium - Names and Identifiers
| Name | cromolyn sodium |
| Synonyms | cromolyn sodium Cromoglycate sodium CROMOGLICATE SODIUM Sodium cromoglycate Sodium Cromoylycate Sodium Cromoglicate Sodium chromoglycate disodium cromoglicate Cromolyn Disodium Salt Disodium 1,3-bis(2-carboxy-5-chromonyloxy)-2-propanol Disodium 5,5-[(2-hydroxytrimethylene)-bis-(oxy)]-bis[4-oxo--1-benzopyran-2 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylic acid) Disodium 5,5'-[(2-hydroxytrimethylene)dioxy]bis[4-oxo-4H-1-benzopyran-2-carboxylate] disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4H-chromene-2-carboxylate) [6-[2-hydroxy-3-(4-oxo-2-sodiooxycarbonyl-chromen-6-yl)oxy-propoxy]-4-oxo-chromene-2-carbonyl]oxysodium |
| CAS | 15826-37-6 |
| EINECS | 239-926-7 |
| InChI | InChI=1/C23H16O11.2Na/c24-11(9-31-12-1-3-18-14(5-12)16(25)7-20(33-18)22(27)28)10-32-13-2-4-19-15(6-13)17(26)8-21(34-19)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2 |
| InChIKey | VLARUOGDXDTHEH-UHFFFAOYSA-L |
Cromoglycate sodium - Physico-chemical Properties
| Molecular Formula | C23H14O11Na2 |
| Molar Mass | 512.33 |
| Melting Point | 241-2420C (dec) |
| Boling Point | 752.3℃ at 760 mmHg |
| Water Solubility | Soluble in water to 100mg/ml |
| Solubility | Soluble in water (100 mg/ml), DMSO (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 |
| Appearance | Shape neat, color White to Off-White |
| Storage Condition | 2-8°C |
| Stability | Hygroscopyc |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00057744 |
| Physical and Chemical Properties | Chemical properties melting point 216-217 ℃. Sodium cromoglycate is a white crystalline powder. Melting point 241-242 ℃ (decomposition). Easily soluble in water (100mg/ml at 20 ℃), insoluble in ethanol and chloroform. It is hygroscopic, odorless, and easy to change color when exposed to light. |
| Use | Antiallergic, for the treatment of allergic asthma |
Cromoglycate sodium - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 2 |
| RTECS | DJ2380000 |
| HS Code | 29329990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (mg/kg): >8000 orally (Cox) |
Cromoglycate sodium - Upstream Downstream Industry
| Raw Materials | Isopropyl alcohol Diethyl oxalate Epichlorohydrin Resorcinol 2',6'-Dihydroxyacetophenone Diethyl cromoglycate Sodium hydroxide |
Cromoglycate sodium - Standard
Authoritative Data Verified Data
This product is 5,5 '-[(2-hydroxy-1, 3-propylidene) dioxo] bis (4-oxo-4h-1 benzopyran-2-carboxylic acid) disodium salt. Calculated as the dried product, the content of C23H14Na2O11 shall not be less than 98.0%.
Last Update：2024-01-02 23:10:35
Cromoglycate sodium - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder; Odorless; Has hygroscopicity; Easy to change color in case of light.
- This product is soluble in water and insoluble in ethanol or chloroform.
Last Update：2022-01-01 11:53:47
Cromoglycate sodium - Introduction
Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.
Last Update：2022-10-16 17:14:11
Cromoglycate sodium - Differential diagnosis
Authoritative Data Verified Data
- take 0.lg of this product, add 2ml of water and 2ml of sodium hydroxide solution, boil for 1 min, the solution shows yellow color, and add several drops of nitrogen benzene sulfonic acid solution, showing blood red.
- take this product, add phosphoric acid twist buffer (pH 7.4) to dissolve and dilute to prepare a solution containing about 10ug per lml, and measure it by UV-Vis spectrophotometry (General 0401), there is a maximum absorption at wavelengths of 238nm and 326nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 155).
- identification reaction of sodium salt in aqueous solution of this product (General rule 0301).
Last Update：2022-01-01 11:53:47
Cromoglycate sodium - Exam
Authoritative Data Verified Data
pH
take 0.10g of this product, Add 10ml of water to dissolve, add 1 drop of bromothymol blue indicator solution; If it is yellow, add 0.01 ml of sodium hydroxide titration solution (0.15 mol/L), and the strain is blue; if Blue, add hydrochloric acid titration solution (0.01mol/L)0.15, the strain is yellow.
oxalate
take 0.10g of this product and oxalic acid reference solution [take oxalic acid (based on Anhydrous) 25mg, put 100ml measuring flask, add water to dissolve and dilute to the scale, shake] 1.0, add 20ml of water and 5.0ml of iron salicylate solution to the 50ml measuring flask, dilute with water to the scale, shake well, and measure the absorbance at the wavelength of 480nm, the absorbance of the test solution shall not be lower than that of the oxalic acid reference solution (0.25%).
loss on drying
take this product, dry to constant weight at 120°C, weight loss shall not exceed 10.0% (General rule 0831).
Heavy metals
This product l.Og, inspection according to law (General Principles 0821 second law), containing heavy metals shall not exceed 10 parts per million.
Last Update：2022-01-01 11:53:48
Cromoglycate sodium - Content determination
Authoritative Data Verified Data
take this product about 0.18g, precision weighing, add propylene glycol 20ml and isopropanol 5ml, heat to dissolve, cool, add dioxane 20ml and methyl orange-xylene blue FF mixed indicator liquid several drops, with perchloric acid titration solution (0.1 mol/L)(prepared with dioxane) titrated to a blue-gray solution. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 25.62mg of C23H14Na2O11.
Last Update：2022-01-01 11:53:49
Cromoglycate sodium - Category
Authoritative Data Verified Data
anti-allergic drugs.
Last Update：2022-01-01 11:53:49
Cromoglycate sodium - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:53:49
Cromoglycate sodium - Sodium Cromoglicate Eye Drops
Authoritative Data Verified Data
This product contains sodium cromoglycate (C23H14Na2O11) should be labeled amount of 90.0% ~ 110.0%.
trait
This product is colorless or almost colorless clear liquid.
identification
- take 5ml of this product, add 2ml of sodium hydroxide solution, boil for 1 min, the solution is yellow, add several drops of nitrogen benzene sulfonic acid solution, blood red.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
examination
- the pH value should be 4.0 to 7.0 (General 0631).
- others shall comply with the relevant provisions under Ophthalmic Preparations (General rule 0105).
Content determination
take 2ml of this product with precision, put it in a 100ml measuring flask, dilute it to scale with phosphate buffer (pH 5.8), shake it well, take 5ml with precision, put it in a 100ml measuring flask, dilute to the scale with phosphate buffer (pH 5.8) and shake. The absorbance was measured at a wavelength of 326mn according to UV-Vis spectrophotometry (General 0401), and the absorbance was calculated as the absorption coefficient (E12) of C23H14Na2O11 was 164.
category
sodium glycinate of the same color.
specification
8ml:0.16g
storage
light shielding, closed storage.
Last Update：2022-01-01 11:53:50
Supplier List
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Product Name: Disodium Cromoglycate (Standard); FPL-670 (Standard) Visit Supplier Webpage Request for quotationCAS: 15826-37-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
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Mobile: 609-228-6898
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Product Name: Sodium cromoglycate Visit Supplier Webpage Request for quotationCAS: 15826-37-6
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Product Name: Cromolyn Disodium Salt Hydrate Visit Supplier Webpage Request for quotationCAS: 15826-37-6
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CAS: 15826-37-6
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CAS: 15826-37-6
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Product Name: Cromolyn Disodium Salt Hydrate Visit Supplier Webpage Request for quotationCAS: 15826-37-6
Tel: +86-18821248368
Email: Int06@meryer.com
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View History
Cromoglycate sodium
Dodecafluoro(4-methyl-2-pentene)
构树碱A
Chloramphenicol hemisuccinate
(S)-(1-甲基吡咯烷-2-基)二苯基甲醇
(2,4,6-trinitrophenyl)amine
Meclizine dihydrochloride monohydrate
weakly acidic acrylic type cation exchange resins
ETHYL 4-PYRIDINECARBONATE
人氨基端前心钠肽检测试剂盒
Dodecafluoro(4-methyl-2-pentene)
构树碱A
Chloramphenicol hemisuccinate
(S)-(1-甲基吡咯烷-2-基)二苯基甲醇
(2,4,6-trinitrophenyl)amine
Meclizine dihydrochloride monohydrate
weakly acidic acrylic type cation exchange resins
ETHYL 4-PYRIDINECARBONATE
人氨基端前心钠肽检测试剂盒
Raw Materials for Cromoglycate sodium